Assay Detail
Functional
CHEMBL796909
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Concentration causing maximal effect on [Ca2+] release from the intracellular stores of permealized hepatocytes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Bicyclic analogues of D-myo-inositol 1,4,5-trisphosphate related to adenophostin A: synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.70 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204385 | ADENOPHOSTIN A | — | 1 | 8.04 |
| CHEMBL279107 | INS(1,4,5)P3 | — | 1 | 7.05 |
| CHEMBL2092836 | — | — | 1 | 5.91 |
| CHEMBL2092858 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204385 | ADENOPHOSTIN A | EC50 | = | 9.2 | nM | 8.04 |
| CHEMBL279107 | INS(1,4,5)P3 | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2092836 | — | EC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL2092858 | — | EC50 | = | 1650.0 | nM | 5.78 |