Assay Detail
Binding
CHEMBL797511
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Inhibition of HIV-1 reverse transcriptase.
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.88 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64233 | — | — | 1 | 7.41 |
| CHEMBL303089 | — | — | 1 | 7.30 |
| CHEMBL62104 | — | — | 1 | 7.27 |
| CHEMBL59458 | — | — | 1 | 7.23 |
| CHEMBL64722 | — | — | 1 | 7.21 |
| CHEMBL60545 | — | — | 1 | 7.17 |
| CHEMBL293037 | — | — | 1 | 7.14 |
| CHEMBL292711 | — | — | 1 | 7.13 |
| CHEMBL62039 | — | — | 1 | 7.13 |
| CHEMBL64521 | — | — | 1 | 7.11 |
| CHEMBL417394 | — | — | 1 | 7.10 |
| CHEMBL62179 | — | — | 1 | 7.04 |
| CHEMBL305345 | — | — | 1 | 6.99 |
| CHEMBL283619 | — | — | 1 | 6.96 |
| CHEMBL293894 | — | — | 1 | 6.96 |
| CHEMBL64467 | — | — | 1 | 6.91 |
| CHEMBL430601 | — | — | 1 | 6.90 |
| CHEMBL302622 | — | — | 1 | 6.89 |
| CHEMBL304028 | — | — | 1 | 6.84 |
| CHEMBL59917 | — | — | 1 | 6.78 |
| CHEMBL302861 | — | — | 1 | 6.74 |
| CHEMBL291662 | — | — | 1 | 6.66 |
| CHEMBL292790 | — | — | 1 | 6.62 |
| CHEMBL291400 | — | — | 1 | 6.56 |
| CHEMBL416853 | — | — | 1 | 6.55 |
| CHEMBL60513 | — | — | 1 | 6.40 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 6.38 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64233 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL303089 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL62104 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL59458 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL64722 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL60545 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL293037 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL292711 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL62039 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL64521 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL417394 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL62179 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL305345 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL283619 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL293894 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL64467 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL430601 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL302622 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL304028 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL59917 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL302861 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL291662 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL292790 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL291400 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL416853 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL60513 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 4848.0 | nM | 5.31 |