Assay Detail
Binding
CHEMBL797533
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In vitro for inhibition of HIV-1 reverse transcriptase.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.64 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 5.96 |
| CHEMBL149055 | — | — | 1 | 5.96 |
| CHEMBL151955 | — | — | 1 | 5.85 |
| CHEMBL356163 | — | — | 1 | 5.75 |
| CHEMBL151173 | — | — | 1 | 5.72 |
| CHEMBL151565 | — | — | 1 | 5.70 |
| CHEMBL358754 | — | — | 1 | 5.70 |
| CHEMBL356173 | — | — | 1 | 5.68 |
| CHEMBL424141 | — | — | 1 | 5.66 |
| CHEMBL124338 | — | — | 1 | 5.66 |
| CHEMBL151192 | — | — | 1 | 5.57 |
| CHEMBL338435 | — | — | 1 | 5.51 |
| CHEMBL147224 | — | — | 1 | 5.50 |
| CHEMBL151316 | — | — | 1 | 5.47 |
| CHEMBL148532 | — | — | 1 | 5.32 |
| CHEMBL280527 | ATEVIRDINE MESYLATE | 2.0 | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL593 | DELAVIRDINE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL149055 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL151955 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL356163 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL151173 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL151565 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL358754 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL356173 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL424141 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL124338 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL151192 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL338435 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL147224 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL151316 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL148532 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL280527 | ATEVIRDINE MESYLATE | IC50 | = | 5200.0 | nM | 5.28 |