Compound Detail
CHEMBL356173
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Basic Information
| ChEMBL ID | CHEMBL356173 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NWMIXFOVOGAALM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names
Molecular Properties
350.4
MW (Da)
2.92
ALogP
4
HBA
1
HBD
61.5
PSA (Ų)
0.79
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 5.68 | 5.68 | 2100.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.1017 | hr | - |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 2100.0 | nM | 5.68 | In vitro for inhibition of HIV-1 reverse transcriptase. | 8978855 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8978855 | 10.1021/jm960269m | Human immunodeficiency virus type 1 reverse transcriptase | 2 |
| 8978855 | 10.1021/jm960269m | Human immunodeficiency virus 1 | 1 |
| 8978855 | 10.1021/jm960269m | ADMET | 1 |
Data from ChEMBL 36 via Core Engine