Assay Detail
Binding
CHEMBL797535
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In vitro inhibition of HIV-1 reverse transcriptase
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]piperazine monomethanesulfonate (U-90152S), a second-generation clinical candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.51 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37056 | — | — | 1 | 6.30 |
| CHEMBL37789 | — | — | 1 | 6.12 |
| CHEMBL37518 | — | — | 1 | 6.00 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 5.96 |
| CHEMBL289969 | — | — | 1 | 5.92 |
| CHEMBL37080 | — | — | 1 | 5.92 |
| CHEMBL38068 | — | — | 1 | 5.89 |
| CHEMBL289304 | — | — | 1 | 5.89 |
| CHEMBL38129 | — | — | 1 | 5.85 |
| CHEMBL36835 | — | — | 1 | 5.75 |
| CHEMBL36656 | — | — | 1 | 5.70 |
| CHEMBL36776 | — | — | 1 | 5.66 |
| CHEMBL415871 | — | — | 1 | 5.60 |
| CHEMBL268871 | L-697661 | — | 1 | 5.57 |
| CHEMBL38088 | — | — | 1 | 5.41 |
| CHEMBL7483 | — | — | 1 | 5.40 |
| CHEMBL417331 | — | — | 1 | 5.37 |
| CHEMBL286325 | — | — | 1 | 5.36 |
| CHEMBL280527 | ATEVIRDINE MESYLATE | 2.0 | 1 | 5.28 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.26 |
| CHEMBL37888 | — | — | 1 | 5.26 |
| CHEMBL34542 | — | — | 1 | 5.25 |
| CHEMBL36479 | — | — | 1 | 5.08 |
| CHEMBL34010 | — | — | 1 | 4.57 |
| CHEMBL287924 | — | — | 1 | 4.47 |
| CHEMBL37994 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37056 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL37789 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL37518 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL289969 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL37080 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL38068 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL289304 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL38129 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL36835 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL36656 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL36776 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL415871 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL268871 | L-697661 | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL38088 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL7483 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL417331 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL286325 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL280527 | ATEVIRDINE MESYLATE | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL37888 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL34542 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL36479 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL34010 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL287924 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL37994 | — | IC50 | = | 37000.0 | nM | 4.43 |