Compound Detail
CHEMBL7483
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Basic Information
| ChEMBL ID | CHEMBL7483 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OPOVDOVPCBBDRF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names
Molecular Properties
349.4
MW (Da)
2.96
ALogP
4
HBA
2
HBD
64.3
PSA (Ų)
0.76
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 5.4 | 5.4 | 4000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.4 | 5.4 | 4000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 4000.0 | nM | 5.4 | In vitro inhibition of HIV-1 reverse transcriptase | 7684450 |
| Unchecked | IC50 | = | 4000.0 | nM | 5.4 | Inhibition of HIV-1 reverse transcriptase assessed as reduction in dTTP incorpor... | 27894873 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7512142 | 10.1021/jm00033a018 | MT2 | 2 |
| 7512142 | 10.1021/jm00033a018 | Unchecked | 2 |
| 7684450 | 10.1021/jm00062a027 | Human immunodeficiency virus type 1 reverse transcriptase | 2 |
| 7684450 | 10.1021/jm00062a027 | Human immunodeficiency virus 1 | 2 |
| 7512142 | 10.1021/jm00033a018 | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
| 7512142 | 10.1021/jm00033a018 | Human immunodeficiency virus 1 | 1 |
| 7512142 | 10.1021/jm00033a018 | ADMET | 1 |
| 7684450 | 10.1021/jm00062a027 | MT2 | 1 |
| 7684450 | 10.1021/jm00062a027 | ADMET | 1 |
| 27894873 | 10.1016/j.bmcl.2016.11.030 | Unchecked | 1 |
| 30516990 | 10.1021/acs.jmedchem.8b00843 | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
Data from ChEMBL 36 via Core Engine