Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL797566

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of histamine release in rat mast cells
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 1 — Organism
Curated By Expert

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

New N-(pyridin-4-yl)-(indol-3-yl)acetamides and propanamides as antiallergic agents.
Menciu C, Duflos M, Fouchard F, Le Baut G, Emig P, Achterrath U, Szelenyi I, Nickel B, Schmidt J, Kutscher B, Günther E.
J Med Chem (1999) 42 : 638 -648
PubMed 10052971 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 5.91 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL160259 1 7.80
CHEMBL160542 1 7.22
CHEMBL158609 1 6.66
CHEMBL158619 1 6.64
CHEMBL348629 1 6.52
CHEMBL348414 1 6.48
CHEMBL160477 1 6.42
CHEMBL160757 1 6.40
CHEMBL352001 1 6.38
CHEMBL159200 1 6.32
CHEMBL346811 1 6.29
CHEMBL158379 1 6.13
CHEMBL157424 1 6.03
CHEMBL160964 1 5.89
CHEMBL162136 1 5.84
CHEMBL156215 1 5.66
CHEMBL156262 1 5.55
CHEMBL155963 1 5.55
CHEMBL435652 1 5.54
CHEMBL156149 1 5.51
CHEMBL157396 1 5.41
CHEMBL160431 1 5.35
CHEMBL160659 1 5.31
CHEMBL156681 1 5.30
CHEMBL422875 1 5.27
CHEMBL155737 1 5.22
CHEMBL296419 ASTEMIZOLE 4.0 1 5.19
CHEMBL156393 1 5.16
CHEMBL156051 1 5.12
CHEMBL158996 1 4.99

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL160259 IC50 = 16.0 nM 7.80
CHEMBL160542 IC50 = 60.0 nM 7.22
CHEMBL158609 IC50 = 220.0 nM 6.66
CHEMBL158619 IC50 = 230.0 nM 6.64
CHEMBL348629 IC50 = 302.0 nM 6.52
CHEMBL348414 IC50 = 330.0 nM 6.48
CHEMBL160477 IC50 = 380.0 nM 6.42
CHEMBL160757 IC50 = 400.0 nM 6.40
CHEMBL352001 IC50 = 420.0 nM 6.38
CHEMBL159200 IC50 = 480.0 nM 6.32
CHEMBL346811 IC50 = 510.0 nM 6.29
CHEMBL158379 IC50 = 740.0 nM 6.13
CHEMBL157424 IC50 = 940.0 nM 6.03
CHEMBL160964 IC50 = 1300.0 nM 5.89
CHEMBL162136 IC50 = 1460.0 nM 5.84
CHEMBL156215 IC50 = 2210.0 nM 5.66
CHEMBL156262 IC50 = 2800.0 nM 5.55
CHEMBL155963 IC50 = 2800.0 nM 5.55
CHEMBL435652 IC50 = 2900.0 nM 5.54
CHEMBL156149 IC50 = 3120.0 nM 5.51
CHEMBL157396 IC50 = 3900.0 nM 5.41
CHEMBL160431 IC50 = 4500.0 nM 5.35
CHEMBL160659 IC50 = 4920.0 nM 5.31
CHEMBL156681 IC50 = 5000.0 nM 5.30
CHEMBL422875 IC50 = 5340.0 nM 5.27
CHEMBL155737 IC50 = 6000.0 nM 5.22
CHEMBL296419 ASTEMIZOLE IC50 = 6500.0 nM 5.19
CHEMBL156393 IC50 = 6900.0 nM 5.16
CHEMBL156051 IC50 = 7540.0 nM 5.12
CHEMBL158996 IC50 = 10130.0 nM 4.99
CHEMBL156822 IC50 > 10000.0 nM -
CHEMBL160228 IC50 > 10000.0 nM -
CHEMBL345393 IC50 > 10000.0 nM -