Assay Detail
Functional
CHEMBL797692
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of neuronal uptake of Noradrenaline in rat brain homogenate
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.52 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117826 | — | — | 1 | 6.70 |
| CHEMBL118752 | — | — | 1 | 6.22 |
| CHEMBL118968 | — | — | 1 | 6.10 |
| CHEMBL118033 | — | — | 1 | 5.85 |
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 5.77 |
| CHEMBL332454 | — | — | 1 | 5.75 |
| CHEMBL60167 | — | — | 1 | 5.64 |
| CHEMBL325203 | — | — | 1 | 5.60 |
| CHEMBL115697 | — | — | 1 | 5.52 |
| CHEMBL119634 | — | — | 1 | 5.44 |
| CHEMBL431844 | — | — | 1 | 5.21 |
| CHEMBL330883 | — | — | 1 | 5.16 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 5.10 |
| CHEMBL89012 | — | — | 1 | 4.92 |
| CHEMBL119528 | — | — | 1 | 4.92 |
| CHEMBL333011 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117826 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL118752 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL118968 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL118033 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL72 | DESIPRAMINE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL332454 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL60167 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL325203 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL115697 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL119634 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL431844 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL330883 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL95 | TACRINE | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL89012 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL119528 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL333011 | — | IC50 | = | 41040.0 | nM | 4.39 |