Assay Detail
Functional
CHEMBL797694
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The IC50 value was measured for inhibition of lipid autoxidation in rat brain homogenate.
26
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Cardioselective ammonium, phosphonium, and sulfonium analogues of alpha-tocopherol and ascorbic acid that inhibit in vitro and ex vivo lipid peroxidation and scavenge superoxide radicals.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.42 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87570 | — | — | 1 | 6.16 |
| CHEMBL451245 | — | — | 1 | 6.00 |
| CHEMBL99819 | — | — | 1 | 6.00 |
| CHEMBL317128 | — | — | 1 | 5.70 |
| CHEMBL1788215 | — | — | 1 | 5.70 |
| CHEMBL2092915 | — | — | 1 | 5.70 |
| CHEMBL95994 | — | — | 1 | 5.70 |
| CHEMBL1788216 | — | — | 1 | 5.70 |
| CHEMBL440885 | — | — | 1 | 5.70 |
| CHEMBL2092916 | — | — | 1 | 5.70 |
| CHEMBL95570 | — | — | 1 | 5.66 |
| CHEMBL317220 | — | — | 1 | 5.64 |
| CHEMBL99134 | — | — | 1 | 5.58 |
| CHEMBL319361 | — | — | 1 | 5.52 |
| CHEMBL2115381 | — | — | 1 | 5.22 |
| CHEMBL98203 | — | — | 1 | 5.22 |
| CHEMBL1788217 | — | — | 1 | 5.10 |
| CHEMBL2092917 | — | — | 1 | 5.05 |
| CHEMBL153 | TROLOX | — | 2 | 4.92 |
| CHEMBL97136 | — | — | 1 | 4.85 |
| CHEMBL319725 | — | — | 1 | 4.85 |
| CHEMBL49563 | alpha-TOCHOPHEROL | — | 1 | 4.85 |
| CHEMBL99143 | — | — | 1 | 4.77 |
| CHEMBL98803 | — | — | 1 | - |
| CHEMBL97262 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87570 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL451245 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL99819 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL317128 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1788215 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2092915 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL95994 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1788216 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL440885 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2092916 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL95570 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL317220 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL99134 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL319361 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2115381 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL98203 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1788217 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2092917 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL153 | TROLOX | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL97136 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL319725 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL153 | TROLOX | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL49563 | alpha-TOCHOPHEROL | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL99143 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL98803 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL97262 | — | IC50 | > | 20000.0 | nM | - |