Assay Detail
Binding
CHEMBL797916
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Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 16 | 7.02 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288436 | — | — | 1 | 8.52 |
| CHEMBL109117 | — | — | 1 | 7.66 |
| CHEMBL1023 | BEXAROTENE | 4.0 | 1 | 7.44 |
| CHEMBL106896 | — | — | 1 | 7.34 |
| CHEMBL25244 | — | — | 1 | 7.30 |
| CHEMBL105979 | — | — | 1 | 6.96 |
| CHEMBL98172 | — | — | 1 | 6.86 |
| CHEMBL106837 | — | — | 1 | 6.75 |
| CHEMBL105805 | — | — | 1 | 6.28 |
| CHEMBL106817 | — | — | 1 | 6.17 |
| CHEMBL108402 | — | — | 1 | 5.94 |
| CHEMBL110629 | — | — | 1 | - |
| CHEMBL108162 | — | — | 1 | - |
| CHEMBL105806 | — | — | 1 | - |
| CHEMBL432587 | — | — | 1 | - |
| CHEMBL107039 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288436 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL109117 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL1023 | BEXAROTENE | Kd | = | 36.0 | nM | 7.44 |
| CHEMBL106896 | — | Kd | = | 46.0 | nM | 7.34 |
| CHEMBL25244 | — | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL105979 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL98172 | — | Kd | = | 138.0 | nM | 6.86 |
| CHEMBL106837 | — | Kd | = | 176.0 | nM | 6.75 |
| CHEMBL105805 | — | Kd | = | 520.0 | nM | 6.28 |
| CHEMBL106817 | — | Kd | = | 670.0 | nM | 6.17 |
| CHEMBL108402 | — | Kd | = | 1159.0 | nM | 5.94 |
| CHEMBL110629 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL108162 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL105806 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL432587 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL107039 | — | Kd | > | 1000.0 | nM | - |