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Compound Detail

CHEMBL107039

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C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)CCCC2(C)C

Basic Information

ChEMBL ID CHEMBL107039
Phase Preclinical
Structure Type MOL
InChI Key CMBRTFQBQGEDHH-UHFFFAOYSA-N
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names

Molecular Properties

320.4
MW (Da)
5.37
ALogP
1
HBA
1
HBD
37.3
PSA (Ų)
0.83
QED
1
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H24O2
MW 320.43
Aromatic Rings 2
Heavy Atoms 24
NP-Likeness 0.76

Activity Summary

EC50 6 meas. best 5.62

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Retinoic acid receptor RXR-beta
CHEMBL1870
EC50 5.62 5.62 2400.0 1
Retinoic acid receptor RXR-alpha
CHEMBL2061
EC50 5.62 5.62 2400.0 2
Retinoic acid receptor RXR-beta
CHEMBL4047
EC50 5.62 5.62 2400.0 1
Retinoic acid receptor RXR-gamma
CHEMBL2004
EC50 5.58 5.58 2600.0 1
Retinoic acid receptor RXR-gamma
CHEMBL4402
EC50 5.58 5.58 2600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
7636877 10.1021/jm00016a018 Retinoic acid receptor RXR-alpha 2
7636877 10.1021/jm00016a018 Retinoic acid receptor RXR-beta 2
7636877 10.1021/jm00016a018 Retinoic acid receptor RXR-gamma 2
28850227 10.1021/acs.jmedchem.7b00315 Retinoic acid receptor RXR-gamma 1
28850227 10.1021/acs.jmedchem.7b00315 Retinoic acid receptor RXR-beta 1
28850227 10.1021/acs.jmedchem.7b00315 Retinoic acid receptor RXR-alpha 1
28850227 10.1021/acs.jmedchem.7b00315 Retinoic acid receptor alpha 1
28850227 10.1021/acs.jmedchem.7b00315 Retinoic acid receptor beta 1
28850227 10.1021/acs.jmedchem.7b00315 Retinoic acid receptor gamma 1

Data from ChEMBL 36 via Core Engine