Assay Detail
Binding
CHEMBL807508
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Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.77 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288436 | — | — | 1 | 8.52 |
| CHEMBL109117 | — | — | 1 | 8.05 |
| CHEMBL106896 | — | — | 1 | 7.66 |
| CHEMBL1023 | BEXAROTENE | 4.0 | 1 | 7.60 |
| CHEMBL106817 | — | — | 1 | 7.17 |
| CHEMBL25244 | — | — | 1 | 6.89 |
| CHEMBL98172 | — | — | 1 | 6.67 |
| CHEMBL106837 | — | — | 1 | 6.55 |
| CHEMBL105979 | — | — | 1 | 6.51 |
| CHEMBL108402 | — | — | 1 | 6.11 |
| CHEMBL432587 | — | — | 1 | 5.92 |
| CHEMBL110629 | — | — | 1 | 5.72 |
| CHEMBL105805 | — | — | 1 | 5.72 |
| CHEMBL107039 | — | — | 1 | 5.62 |
| CHEMBL108162 | — | — | 1 | - |
| CHEMBL105806 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288436 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL109117 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL106896 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1023 | BEXAROTENE | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL106817 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL25244 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL98172 | — | EC50 | = | 213.0 | nM | 6.67 |
| CHEMBL106837 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL105979 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL108402 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL432587 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL110629 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL105805 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL107039 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL108162 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL105806 | — | EC50 | > | 10000.0 | nM | - |