Assay Detail
Binding
CHEMBL798968
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Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.87 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288436 | — | — | 1 | 8.40 |
| CHEMBL109117 | — | — | 1 | 8.30 |
| CHEMBL106896 | — | — | 1 | 7.77 |
| CHEMBL1023 | BEXAROTENE | 4.0 | 1 | 7.70 |
| CHEMBL106817 | — | — | 1 | 7.33 |
| CHEMBL25244 | — | — | 1 | 6.62 |
| CHEMBL98172 | — | — | 1 | 6.61 |
| CHEMBL105979 | — | — | 1 | 6.47 |
| CHEMBL105805 | — | — | 1 | 6.37 |
| CHEMBL432587 | — | — | 1 | 6.36 |
| CHEMBL106837 | — | — | 1 | 6.30 |
| CHEMBL108402 | — | — | 1 | 6.22 |
| CHEMBL110629 | — | — | 1 | 6.19 |
| CHEMBL107039 | — | — | 1 | 5.58 |
| CHEMBL108162 | — | — | 1 | - |
| CHEMBL105806 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288436 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL109117 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL106896 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1023 | BEXAROTENE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL106817 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL25244 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL98172 | — | EC50 | = | 246.0 | nM | 6.61 |
| CHEMBL105979 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL105805 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL432587 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL106837 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL108402 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL110629 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL107039 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL108162 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL105806 | — | EC50 | > | 10000.0 | nM | - |