Assay Detail
Functional
CHEMBL798105
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In vitro reduction in blood pressure relative to maximum achieved with the K-ATP standard P1075 in spontaneously hypertensive rat
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Blood |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of a novel series of tricyclic dihydropyridine-based KATP openers that potently inhibit bladder contractions in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.13 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110399 | — | — | 1 | 6.40 |
| CHEMBL3138607 | — | — | 1 | 6.37 |
| CHEMBL320518 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110399 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL3138607 | — | EC50 | = | 426.58 | nM | 6.37 |
| CHEMBL320518 | — | EC50 | = | 2454.71 | nM | 5.61 |