Compound Detail
CHEMBL110399
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Basic Information
| ChEMBL ID | CHEMBL110399 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GISAKNBHIDHKQY-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
366.1
MW (Da)
2.74
ALogP
5
HBA
1
HBD
68.1
PSA (Ų)
0.78
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 7.63
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sulfonylurea receptors; K-ATP channels CHEMBL2095152 | EC50 | 7.63 | 7.0433 | 23.4 | 3 |
| Unchecked CHEMBL612545 | EC50 | 6.4 | 6.4 | 398.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sulfonylurea receptors; K-ATP channels | EC50 | = | 23.44 | nM | 7.63 | Evaluated for K-ATP activity as in vitro bladder relaxation in spontaneous Landr... | 15163197 |
| Sulfonylurea receptors; K-ATP channels | EC50 | = | 63.1 | nM | 7.2 | Evaluated for K-ATP activity in terms of membrane potential change, through guin... | 15163197 |
| Unchecked | EC50 | = | 398.11 | nM | 6.4 | In vitro reduction in blood pressure relative to maximum achieved with the K-ATP... | 15163197 |
| Sulfonylurea receptors; K-ATP channels | EC50 | = | 501.19 | nM | 6.3 | K-ATP activity in terms of stable twitch response through field-stimulated landr... | 15163197 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15163197 | 10.1021/jm030357o | Sulfonylurea receptors; K-ATP channels | 3 |
| 15163197 | 10.1021/jm030357o | Unchecked | 2 |
Data from ChEMBL 36 via Core Engine