Sulfonylurea receptors; K-ATP channels · PROTEIN COMPLEX GROUP · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q14654. Use UniProt Q14654 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q14654 as the stable identity anchor, then attach disease evidence before program review.
ATP-sensitive inward rectifier potassium channel 11
Review this target as Sulfonylurea receptors; K-ATP channels, mapped to UniProt Q14654. ChEMBL maps the protein component as ATP-sensitive inward rectifier potassium channel 11. Sequence length is 390 aa.
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This review treats Sulfonylurea receptors; K-ATP channels as ChEMBL target CHEMBL2095152, mapped to UniProt Q14654. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Sulfonylurea receptors; K-ATP channels |
| Target Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
| UniProt | Q14654 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | ATP-sensitive inward rectifier potassium channel 11 |
| UniProt Accession | Q14654 |
| Component Type | Protein |
| Sequence Length | 390 aa |
ATP-sensitive inward rectifier potassium channel 11
Review this target as Sulfonylurea receptors; K-ATP channels, mapped to UniProt Q14654. ChEMBL maps the protein component as ATP-sensitive inward rectifier potassium channel 11. Sequence length is 390 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL321455 | 9.27 | EC50 | 0.537 | Preclinical |
| CHEMBL2111694 | 8.3 | EC50 | 5.012 | Preclinical |
| CHEMBL3138573 | 8.3 | EC50 | 5.012 | Preclinical |
| CHEMBL323159 | 8.2 | EC50 | 6.31 | Preclinical |
| CHEMBL3392139 | 8.06 | EC50 | 8.71 | Preclinical |
| CHEMBL50760 | 8.05 | EC50 | 8.913 | Preclinical |
| CHEMBL3138553 | 7.9 | EC50 | 12.59 | Preclinical |
| CHEMBL108723 | 7.89 | EC50 | 12.88 | Preclinical |
| CHEMBL108251 | 7.85 | EC50 | 14.13 | Preclinical |
| CHEMBL49035 | 7.7 | IC50 | 20.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 19 | 151 | 6.0 |
| tissue-based format | 15 | 8 | 6.5 |
| cell membrane format | 2 | 106 | 6.5 |
| cell-based format | 2 | 25 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 5 | 13 | 5.6 |