Compound Detail
CHEMBL3138553
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Basic Information
| ChEMBL ID | CHEMBL3138553 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LHVKVMMIMWOYFR-OAHLLOKOSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
412.3
MW (Da)
3.31
ALogP
4
HBA
1
HBD
63.2
PSA (Ų)
0.77
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 7.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sulfonylurea receptors; K-ATP channels CHEMBL2095152 | EC50 | 7.9 | 7.4733 | 12.6 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sulfonylurea receptors; K-ATP channels | EC50 | = | 12.59 | nM | 7.9 | Evaluated for K-ATP activity as in vitro bladder relaxation in spontaneous Landr... | 15163196 |
| Sulfonylurea receptors; K-ATP channels | EC50 | = | 43.65 | nM | 7.36 | Evaluated for K-ATP activity in terms of change in membrane potential through gu... | 15163196 |
| Sulfonylurea receptors; K-ATP channels | EC50 | = | 69.18 | nM | 7.16 | Evaluated for K-ATP activity as stable twitch response through field-stimulated ... | 15163196 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15163196 | 10.1021/jm030356w | Sulfonylurea receptors; K-ATP channels | 3 |
| 15163196 | 10.1021/jm030356w | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine