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Assay Detail

CHEMBL798106

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Molar concentration required to relax rat aorta precontracted with 30 mM KCL by 50% of intrinsic activity
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Aorta
Confidence 1 — Organism
Curated By Intermediate

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

Comparative molecular field analysis of benzopyran-4-carbothioamide potassium channel openers
Ohta M, Koga H, Sato H, Ishizawa T
Bioorg Med Chem Lett (1994) 4 : 2903 -2906
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 13 7.40 8.87

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL297457 1 8.87
CHEMBL45322 1 8.69
CHEMBL44369 1 8.39
CHEMBL44370 1 8.03
CHEMBL296891 1 7.90
CHEMBL45368 1 7.72
CHEMBL45314 1 7.61
CHEMBL295351 1 7.43
CHEMBL327950 1 7.02
CHEMBL417178 1 6.49
CHEMBL46994 1 6.38
CHEMBL298309 1 6.34
CHEMBL42605 1 5.37

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL297457 EC50 = 1.349 nM 8.87
CHEMBL45322 EC50 = 2.042 nM 8.69
CHEMBL44369 EC50 = 4.074 nM 8.39
CHEMBL44370 EC50 = 9.333 nM 8.03
CHEMBL296891 EC50 = 12.59 nM 7.90
CHEMBL45368 EC50 = 19.05 nM 7.72
CHEMBL45314 EC50 = 24.55 nM 7.61
CHEMBL295351 EC50 = 37.15 nM 7.43
CHEMBL327950 EC50 = 95.5 nM 7.02
CHEMBL417178 EC50 = 323.59 nM 6.49
CHEMBL46994 EC50 = 416.87 nM 6.38
CHEMBL298309 EC50 = 457.09 nM 6.34
CHEMBL42605 EC50 = 4265.8 nM 5.37