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Assay Detail

CHEMBL798108

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Relaxation of rat aorta smooth muscle precontracted with 30 mM KCl (Negative logarithm of molar concentration required)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Muscle tissue
Confidence 1 — Organism
Curated By Expert

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

Benzopyran-4-carboxamide K+ channel openers
Koga H, Sato H, Ishizawa T, Kuromaru K, Makino T, Taka N, Takahashi T, Sato T, Nabata H
Bioorg Med Chem Lett (1993) 3 : 1115 -1118
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 16 7.37 8.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL13801 1 8.55
CHEMBL13872 1 8.34
CHEMBL13873 1 8.24
CHEMBL13945 1 8.18
CHEMBL13722 1 8.10
CHEMBL13928 1 7.97
CHEMBL13703 1 7.69
CHEMBL13951 1 7.66
CHEMBL276661 1 7.49
CHEMBL11684 (-)-CROMAKALIM 1 6.77
CHEMBL13702 1 6.74
CHEMBL13394 1 6.73
CHEMBL13996 1 6.58
CHEMBL266862 1 6.44
CHEMBL1563246 1 6.28
CHEMBL1159 PINACIDIL ANHYDROUS 4.0 1 6.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL13801 EC50 = 2.818 nM 8.55
CHEMBL13872 EC50 = 4.571 nM 8.34
CHEMBL13873 EC50 = 5.754 nM 8.24
CHEMBL13945 EC50 = 6.607 nM 8.18
CHEMBL13722 EC50 = 7.943 nM 8.10
CHEMBL13928 EC50 = 10.72 nM 7.97
CHEMBL13703 EC50 = 20.42 nM 7.69
CHEMBL13951 EC50 = 21.88 nM 7.66
CHEMBL276661 EC50 = 32.36 nM 7.49
CHEMBL11684 (-)-CROMAKALIM EC50 = 169.82 nM 6.77
CHEMBL13702 EC50 = 181.97 nM 6.74
CHEMBL13394 EC50 = 186.21 nM 6.73
CHEMBL13996 EC50 = 263.03 nM 6.58
CHEMBL266862 EC50 = 363.08 nM 6.44
CHEMBL1563246 EC50 = 524.81 nM 6.28
CHEMBL1159 PINACIDIL ANHYDROUS EC50 = 724.44 nM 6.14