Assay Detail
Functional
CHEMBL798112
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Tested for effective concentration against 5-HT mediated depolarization of isolated rat vagus nerve
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N-(Quinuclidin-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxo-acetamide: a high affinity 5-HT3 receptor partial agonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.09 | 7.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294649 | — | — | 1 | 7.45 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.01 |
| CHEMBL298612 | — | — | 1 | 5.67 |
| CHEMBL266591 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294649 | — | EC50 | = | 35.48 | nM | 7.45 |
| CHEMBL39 | SEROTONIN | EC50 | = | 977.24 | nM | 6.01 |
| CHEMBL298612 | — | EC50 | = | 2137.96 | nM | 5.67 |
| CHEMBL266591 | — | EC50 | = | 6165.95 | nM | 5.21 |