Assay Detail
Functional
CHEMBL798275
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated for agonist sensitivity to antagonist NBQX
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Resolution, absolute stereochemistry, and pharmacology of the S-(+)- and R-(-)-isomers of the apparent partial AMPA receptor agonist (R,S)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid [(R,S)-APPA].
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.09 | 6.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 6.56 |
| CHEMBL83720 | — | — | 1 | 6.30 |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | Ki | = | 275.42 | nM | 6.56 |
| CHEMBL83720 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL275040 | KAINIC ACID | Ki | = | 3801.89 | nM | 5.42 |