Assay Detail
Binding
CHEMBL798355
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Compound was evaluated for its ability to inhibit HIV-1 Reverse Transcriptase in an in vitro enzyme assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
4,1-Benzoxazepinone analogues of efavirenz (Sustiva) as HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.61 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29274 | — | — | 1 | 7.64 |
| CHEMBL283619 | — | — | 1 | 7.50 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.42 |
| CHEMBL31977 | — | — | 1 | 7.34 |
| CHEMBL2114369 | — | — | 1 | 7.09 |
| CHEMBL2114370 | — | — | 1 | 7.02 |
| CHEMBL29171 | — | — | 1 | 6.97 |
| CHEMBL287650 | — | — | 1 | 6.89 |
| CHEMBL30752 | — | — | 1 | 6.82 |
| CHEMBL2114371 | — | — | 1 | 6.77 |
| CHEMBL281230 | — | — | 1 | 6.76 |
| CHEMBL284065 | — | — | 1 | 6.73 |
| CHEMBL31771 | — | — | 1 | 6.71 |
| CHEMBL31285 | — | — | 1 | 6.63 |
| CHEMBL2115317 | — | — | 1 | 6.60 |
| CHEMBL32290 | — | — | 1 | 6.37 |
| CHEMBL283614 | — | — | 1 | 6.37 |
| CHEMBL32038 | — | — | 1 | 6.22 |
| CHEMBL283630 | — | — | 1 | 6.10 |
| CHEMBL281239 | — | — | 1 | 6.02 |
| CHEMBL2115319 | — | — | 1 | 5.94 |
| CHEMBL2115318 | — | — | 1 | 5.71 |
| CHEMBL31455 | — | — | 1 | 5.60 |
| CHEMBL32460 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29274 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL283619 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL31977 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2114369 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2114370 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL29171 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL287650 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL30752 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL2114371 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL281230 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL284065 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL31771 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL31285 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL2115317 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL32290 | — | IC50 | = | 432.0 | nM | 6.37 |
| CHEMBL283614 | — | IC50 | = | 423.0 | nM | 6.37 |
| CHEMBL32038 | — | IC50 | = | 597.0 | nM | 6.22 |
| CHEMBL283630 | — | IC50 | = | 799.0 | nM | 6.10 |
| CHEMBL281239 | — | IC50 | = | 964.0 | nM | 6.02 |
| CHEMBL2115319 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL2115318 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL31455 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL32460 | — | IC50 | = | 3300.0 | nM | 5.48 |