Compound Detail
CHEMBL29274
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL29274 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UXDWYQAXEGVSPS-GFUIURDCSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names
Molecular Properties
316.7
MW (Da)
4.20
ALogP
1
HBA
2
HBD
41.1
PSA (Ų)
0.79
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase CHEMBL247 | IC50 | 7.64 | 7.64 | 23.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 23.0 | nM | 7.64 | Compound was evaluated for its ability to inhibit HIV-1 Reverse Transcriptase in... | 11378361 |
| Human immunodeficiency virus type 1 reverse transcriptase | IC50 | = | 23.0 | nM | 7.64 | Inhibition of HIV1 reverse transcriptase | 26708112 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10821714 | 10.1021/jm990580e | Human immunodeficiency virus 1 | 12 |
| 10821714 | 10.1021/jm990580e | MT2 | 5 |
| 11212098 | 10.1016/s0960-894x(00)00662-4 | Human immunodeficiency virus type 1 protease | 3 |
| 11378361 | 10.1016/s0960-894x(01)00239-6 | Human immunodeficiency virus type 1 reverse transcriptase | 3 |
| 11206461 | 10.1016/s0960-894x(00)00624-7 | Human immunodeficiency virus type 1 protease | 2 |
| 10821714 | 10.1021/jm990580e | Homo sapiens | 2 |
| 11212098 | 10.1016/s0960-894x(00)00662-4 | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
| 11206461 | 10.1016/s0960-894x(00)00624-7 | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
| 15743172 | 10.1021/jm040158k | Cell line | 1 |
| 26708112 | 10.1016/j.ejmech.2015.11.025 | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
| 37393791 | 10.1016/j.ejmech.2023.115586 | Human immunodeficiency virus 1 | 1 |
Data from ChEMBL 36 via Core Engine