Assay Detail
Functional
CHEMBL798398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The ability to inhibit the 5-HT-induced contraction of isolated rat fundus muscle was determined
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationships for hallucinogenic N,N-dialkyltryptamines: photoelectron spectra and serotonin receptor affinities of methylthio and methylenedioxy derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 6.26 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 7.08 |
| CHEMBL31783 | — | — | 1 | 6.84 |
| CHEMBL28354 | — | — | 1 | 6.40 |
| CHEMBL285355 | — | — | 1 | 6.21 |
| CHEMBL32029 | — | — | 1 | 6.17 |
| CHEMBL12420 | N,N-DIMETHYLTRYPTAMINE | 2.0 | 1 | 6.00 |
| CHEMBL283686 | — | — | 1 | 5.99 |
| CHEMBL417480 | — | — | 1 | 5.92 |
| CHEMBL281408 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7257 | MEBUFOTENIN | Kd | = | 83.18 | nM | 7.08 |
| CHEMBL31783 | — | Kd | = | 144.54 | nM | 6.84 |
| CHEMBL28354 | — | Kd | = | 398.11 | nM | 6.40 |
| CHEMBL285355 | — | Kd | = | 616.6 | nM | 6.21 |
| CHEMBL32029 | — | Kd | = | 676.08 | nM | 6.17 |
| CHEMBL12420 | N,N-DIMETHYLTRYPTAMINE | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL283686 | — | Kd | = | 1023.29 | nM | 5.99 |
| CHEMBL417480 | — | Kd | = | 1202.26 | nM | 5.92 |
| CHEMBL281408 | — | Kd | = | 1698.24 | nM | 5.77 |