Assay Detail
Functional
CHEMBL798402
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The negative logarithm of the concentration of the antagonist that requires 2-fold higher concentration of the agonist to release LH from cultured rat pituitary cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Pituitary gland cell |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The effect of NMeTyr5 substitution in luteinizing hormone-releasing hormone antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 10.63 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409219 | — | — | 1 | 10.80 |
| CHEMBL409990 | — | — | 1 | 10.63 |
| CHEMBL438829 | — | — | 1 | 10.45 |
| CHEMBL268319 | — | — | 1 | - |
| CHEMBL268397 | — | — | 1 | - |
| CHEMBL263839 | — | — | 1 | - |
| CHEMBL263840 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409219 | — | Kd | = | 0.01585 | nM | 10.80 |
| CHEMBL409990 | — | Kd | = | 0.02344 | nM | 10.63 |
| CHEMBL438829 | — | Kd | = | 0.03548 | nM | 10.45 |
| CHEMBL268319 | — | Kd | = | 0.00871 | nM | - |
| CHEMBL268397 | — | Kd | = | 0.005012 | nM | - |
| CHEMBL263839 | — | Kd | = | 0.005888 | nM | - |
| CHEMBL263840 | — | Kd | = | 0.006457 | nM | - |