Assay Detail
Functional
CHEMBL798404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The pA2 is the negative logarithm of the molar concentration of an antagonist which necessitates the doubling of the agonist dose to couteract the effect of that antagonist and restore the original response was measured in rat isolated vagus nerve test.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 9.47 | 9.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103778 | CILANSETRON | 2.0 | 1 | 9.94 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 8.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103778 | CILANSETRON | Kd | = | 0.1148 | nM | 9.94 |
| CHEMBL46 | ONDANSETRON | Kd | = | 1.023 | nM | 8.99 |