Assay Detail
Functional
CHEMBL798411
Review assay metadata, readout intent, target linkage, and publication context from the same page.
pA2 value was determined from regression analysis of log (dose ratio-1) vs -log [antagonist] (isolated uterus from DES-pretreated rats)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Uterus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of a novel class of cyclic hexapeptide oxytocin antagonists based on a natural product.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.60 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112248 | — | — | 1 | 8.82 |
| CHEMBL435021 | — | — | 1 | 8.59 |
| CHEMBL2112249 | — | — | 1 | 8.53 |
| CHEMBL338308 | — | — | 1 | 8.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112248 | — | Kd | = | 1.514 | nM | 8.82 |
| CHEMBL435021 | — | Kd | = | 2.57 | nM | 8.59 |
| CHEMBL2112249 | — | Kd | = | 2.951 | nM | 8.53 |
| CHEMBL338308 | — | Kd | = | 3.388 | nM | 8.47 |