Assay Detail
Functional
CHEMBL798532
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Compound was evaluated for the inhibition of binding of [125I]CGP23996 to rat brain membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.38 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437283 | — | — | 1 | 6.16 |
| CHEMBL274400 | — | — | 1 | 6.13 |
| CHEMBL440061 | — | — | 1 | 6.02 |
| CHEMBL384284 | — | — | 1 | 5.64 |
| CHEMBL263342 | — | — | 1 | 4.88 |
| CHEMBL413950 | — | — | 1 | 4.84 |
| CHEMBL274298 | — | — | 1 | 4.73 |
| CHEMBL507214 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437283 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL274400 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL440061 | — | IC50 | = | 947.0 | nM | 6.02 |
| CHEMBL384284 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL263342 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL413950 | — | IC50 | = | 14330.0 | nM | 4.84 |
| CHEMBL274298 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL507214 | — | IC50 | = | 24330.0 | nM | 4.61 |