Assay Detail
Functional
CHEMBL798533
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Compound was tested for 50% Inhibition of lipid peroxidation in rat brain homogenate
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3,5-Disubstituted-4-hydroxyphenyls linked to 3-hydroxy-2-methyl-4(1H)-pyridinone: potent inhibitors of lipid peroxidation and cell toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.61 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96250 | — | — | 1 | 6.52 |
| CHEMBL93440 | — | — | 1 | 6.40 |
| CHEMBL415316 | — | — | 1 | 6.00 |
| CHEMBL94331 | — | — | 1 | 5.70 |
| CHEMBL319659 | — | — | 1 | 5.48 |
| CHEMBL70927 | DEFERIPRONE | 4.0 | 1 | 5.41 |
| CHEMBL96606 | — | — | 1 | 4.83 |
| CHEMBL153 | TROLOX | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96250 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL93440 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL415316 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL94331 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL319659 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL70927 | DEFERIPRONE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL96606 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL153 | TROLOX | IC50 | = | 28700.0 | nM | 4.54 |