Assay Detail
Functional
CHEMBL798696
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the displacement of [3H]gallopamil from specific binding sites on rat myocardial membrane particulates
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Myocardium |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Studies on Ca2+ channel antagonists. 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2- isopropylpentyl isothiocyanate, a chemoaffinity ligand derived from verapamil.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.46 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51149 | GALLOPAMIL | 2.0 | 1 | 6.47 |
| CHEMBL51474 | — | — | 1 | 6.47 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51149 | GALLOPAMIL | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL51474 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 362.0 | nM | 6.44 |