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Assay Detail

CHEMBL798755

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Electropharmacology on rat cortical slice preparation for EAA-evoked depolarizations;Depolarization evoked by the compound is partially antagonised by 5 uM of NBQX and fully antagonised by 20 uM of NBQX.
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 1 — Organism
Curated By Intermediate

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists.
Conti P, De Amici M, De Sarro G, Rizzo M, Stensbøl TB, Bräuner-Osborne H, Madsen U, Toma L, De Micheli C.
J Med Chem (1999) 42 : 4099 -4107
PubMed 10514280 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 5.46 5.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL125440 1 5.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL125440 EC50 = 3500.0 nM 5.46