Assay Detail
Functional
CHEMBL798758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]dopamine reuptake in rat cytosol
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Rational design and synthesis of novel 2,5-disubstituted cis- and trans-piperidine derivatives exhibiting differential activity for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.13 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40607 | — | — | 2 | 7.54 |
| CHEMBL39262 | — | — | 1 | 7.30 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40607 | — | IC50 | = | 28.9 | nM | 7.54 |
| CHEMBL39262 | — | IC50 | = | 49.6 | nM | 7.30 |
| CHEMBL40607 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL370805 | COCAINE | IC50 | = | 191.0 | nM | 6.72 |