Assay Detail
Functional
CHEMBL798761
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative logarithm of the molar concentration of compound required to relax rat aorta precontracted with 30 mM KCl by 50%
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design of potent K+ channel openers by pharmacophore model
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.70 | 7.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45314 | — | — | 1 | 7.61 |
| CHEMBL75020 | — | — | 1 | 7.04 |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 6.77 |
| CHEMBL13996 | — | — | 1 | 6.58 |
| CHEMBL13613 | — | — | 1 | 6.47 |
| CHEMBL1563246 | — | — | 1 | 6.28 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45314 | — | EC50 | = | 24.55 | nM | 7.61 |
| CHEMBL75020 | — | EC50 | = | 91.2 | nM | 7.04 |
| CHEMBL49035 | CROMAKALIM | EC50 | = | 169.82 | nM | 6.77 |
| CHEMBL13996 | — | EC50 | = | 263.03 | nM | 6.58 |
| CHEMBL13613 | — | EC50 | = | 338.84 | nM | 6.47 |
| CHEMBL1563246 | — | EC50 | = | 524.81 | nM | 6.28 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | EC50 | = | 724.44 | nM | 6.14 |