Assay Detail
Functional
CHEMBL798831
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Ability to inhibit after-hyperpolarization (AHP) in cultured rat sympathetic neurons. (number of neurons tested, n=3).
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Sympathetic neuron |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of dequalinium analogues as K+ channel blockers. Investigations on the role of the charged heterocycle.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.17 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL350909 | — | — | 1 | 5.80 |
| CHEMBL1161379 | — | — | 1 | 5.26 |
| CHEMBL156475 | — | — | 1 | 5.26 |
| CHEMBL39463 | — | — | 1 | 5.17 |
| CHEMBL350038 | — | — | 1 | 5.02 |
| CHEMBL346546 | — | — | 1 | 4.92 |
| CHEMBL539872 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL350909 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1161379 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL156475 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL39463 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL350038 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL346546 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL539872 | — | IC50 | = | 18000.0 | nM | 4.75 |