Assay Detail
Functional
CHEMBL798833
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit after-hyperpolarization (AHP) in cultured rat sympathetic neurons. (number of neurons tested, n=5).
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Sympathetic neuron |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure-activity relationships of dequalinium analogues as K+ channel blockers. Investigations on the role of the charged heterocycle.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.15 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117111 | — | — | 1 | 6.00 |
| CHEMBL157563 | — | — | 1 | 5.33 |
| CHEMBL225577 | — | — | 1 | 4.68 |
| CHEMBL157611 | — | — | 1 | 4.60 |
| CHEMBL155555 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117111 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL157563 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL225577 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL157611 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL155555 | — | IC50 | > | 10000.0 | nM | - |