Assay Detail
Binding
CHEMBL798967
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Transcriptional activation of Retinoid X receptor RXR gamma
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cercopithecidae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.21 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116886 | — | — | 1 | 7.38 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 6.85 |
| CHEMBL118693 | — | — | 1 | 6.55 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 5.96 |
| CHEMBL119781 | — | — | 1 | 5.80 |
| CHEMBL324960 | — | — | 1 | 5.80 |
| CHEMBL118268 | — | — | 1 | 5.72 |
| CHEMBL118307 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116886 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL705 | ALITRETINOIN | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL118693 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL38 | TRETINOIN | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL119781 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL324960 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL118268 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL118307 | — | EC50 | = | 2600.0 | nM | 5.58 |