Assay Detail
Binding
CHEMBL798970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective potency in transcriptional activation assay in CV-1 cells expressing Retinoid X receptor RXR gamma
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of potent retinoid X receptor ligands
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.57 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310047 | — | — | 1 | 8.52 |
| CHEMBL80236 | — | — | 1 | 8.22 |
| CHEMBL312395 | — | — | 1 | 7.80 |
| CHEMBL1023 | BEXAROTENE | 4.0 | 1 | 7.70 |
| CHEMBL311113 | — | — | 1 | 7.60 |
| CHEMBL79234 | — | — | 1 | 7.40 |
| CHEMBL75814 | — | — | 1 | 7.36 |
| CHEMBL312737 | — | — | 1 | 6.89 |
| CHEMBL312233 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310047 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL80236 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL312395 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1023 | BEXAROTENE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL311113 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL79234 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL75814 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL312737 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL312233 | — | EC50 | = | 212.0 | nM | 6.67 |