Assay Detail
Functional
CHEMBL799243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of amylase release stimulated by CCK-8 (0.1 nM) in dispersed pancreatic acini
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1)receptor antagonists: structure-activity relationship studies on the substituent at N2-position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.85 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113718 | IQM-95333 | — | 1 | 9.19 |
| CHEMBL366344 | — | — | 1 | 9.14 |
| CHEMBL2114081 | — | — | 1 | 8.72 |
| CHEMBL2111545 | — | — | 1 | 8.52 |
| CHEMBL189634 | — | — | 1 | 8.46 |
| CHEMBL2115133 | — | — | 1 | 8.05 |
| CHEMBL2111550 | — | — | 1 | 8.00 |
| CHEMBL2112237 | — | — | 1 | 7.90 |
| CHEMBL2111549 | — | — | 1 | 7.78 |
| CHEMBL71996 | — | — | 1 | 7.42 |
| CHEMBL2114079 | — | — | 1 | 7.40 |
| CHEMBL2111548 | — | — | 1 | 7.30 |
| CHEMBL2111547 | — | — | 1 | 7.19 |
| CHEMBL116127 | — | — | 1 | 7.11 |
| CHEMBL2114084 | — | — | 1 | 6.95 |
| CHEMBL2112233 | — | — | 1 | 6.54 |
| CHEMBL2111552 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113718 | IQM-95333 | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL366344 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL2114081 | — | IC50 | = | 1.89 | nM | 8.72 |
| CHEMBL2111545 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL189634 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL2115133 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2111550 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2112237 | — | IC50 | = | 12.63 | nM | 7.90 |
| CHEMBL2111549 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL71996 | — | IC50 | = | 38.1 | nM | 7.42 |
| CHEMBL2114079 | — | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL2111548 | — | IC50 | = | 49.5 | nM | 7.30 |
| CHEMBL2111547 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL116127 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2114084 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL2112233 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL2111552 | — | IC50 | > | 1000.0 | nM | - |