Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL799317

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration to inhibit growth of v-src-transformed cells (SR-3Y1 cells) after 72 h exposure
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol.
Ikuina Y, Amishiro N, Miyata M, Narumi H, Ogawa H, Akiyama T, Shiotsu Y, Akinaga S, Murakata C.
J Med Chem (2003) 46 : 2534 -2541
PubMed 12773056 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 7.05 8.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL313882 1 8.24
CHEMBL83069 1 8.21
CHEMBL313587 1 8.01
CHEMBL314705 1 7.70
CHEMBL85730 1 7.70
CHEMBL85011 1 7.58
CHEMBL83305 1 7.29
CHEMBL315521 1 7.24
CHEMBL414883 RADICICOL 1 7.23
CHEMBL84564 1 7.08
CHEMBL85010 1 7.03
CHEMBL85612 1 7.00
CHEMBL311607 1 6.92
CHEMBL82750 1 6.89
CHEMBL84714 1 6.62
CHEMBL419849 1 6.54
CHEMBL315575 1 6.33
CHEMBL84809 1 5.96
CHEMBL82435 1 5.82
CHEMBL84955 1 5.64
CHEMBL85583 1 -
CHEMBL83070 1 -
CHEMBL85532 1 -
CHEMBL312559 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL313882 IC50 = 5.7 nM 8.24
CHEMBL83069 IC50 = 6.1 nM 8.21
CHEMBL313587 IC50 = 9.8 nM 8.01
CHEMBL314705 IC50 = 20.0 nM 7.70
CHEMBL85730 IC50 = 20.0 nM 7.70
CHEMBL85011 IC50 = 26.0 nM 7.58
CHEMBL83305 IC50 = 51.0 nM 7.29
CHEMBL315521 IC50 = 58.0 nM 7.24
CHEMBL414883 RADICICOL IC50 = 59.0 nM 7.23
CHEMBL84564 IC50 = 84.0 nM 7.08
CHEMBL85010 IC50 = 93.0 nM 7.03
CHEMBL85612 IC50 = 100.0 nM 7.00
CHEMBL311607 IC50 = 120.0 nM 6.92
CHEMBL82750 IC50 = 130.0 nM 6.89
CHEMBL84714 IC50 = 240.0 nM 6.62
CHEMBL419849 IC50 = 290.0 nM 6.54
CHEMBL315575 IC50 = 470.0 nM 6.33
CHEMBL84809 IC50 = 1100.0 nM 5.96
CHEMBL82435 IC50 = 1500.0 nM 5.82
CHEMBL84955 IC50 = 2300.0 nM 5.64
CHEMBL85583 IC50 > 3000.0 nM -
CHEMBL83070 IC50 < 4.1 nM -
CHEMBL85532 IC50 > 3000.0 nM -
CHEMBL312559 IC50 > 3000.0 nM -