Assay Detail
Binding
CHEMBL799701
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Transcriptional activation of Retinoic acid receptor RAR alpha
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.78 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.30 |
| CHEMBL275311 | — | — | 1 | 7.68 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 6.99 |
| CHEMBL92926 | — | — | 1 | 5.57 |
| CHEMBL32505 | — | — | 1 | 5.34 |
| CHEMBL96829 | — | — | 1 | - |
| CHEMBL93628 | — | — | 1 | - |
| CHEMBL91718 | — | — | 1 | - |
| CHEMBL316336 | — | — | 1 | - |
| CHEMBL93985 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL275311 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL705 | ALITRETINOIN | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL92926 | — | EC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL32505 | — | EC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL96829 | — | EC50 | > | 0.001 | nM | - |
| CHEMBL93628 | — | EC50 | > | 0.001 | nM | - |
| CHEMBL91718 | — | EC50 | > | 0.001 | nM | - |
| CHEMBL316336 | — | EC50 | > | 0.001 | nM | - |
| CHEMBL93985 | — | EC50 | > | 0.001 | nM | - |