Compound Detail
CHEMBL92926
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Basic Information
| ChEMBL ID | CHEMBL92926 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GAZWXMUOJOGOHH-RVDMUPIBSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
363.5
MW (Da)
6.00
ALogP
2
HBA
1
HBD
50.2
PSA (Ų)
0.73
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 7.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Retinoic acid receptor beta CHEMBL2008 | EC50 | 7.68 | 7.68 | 21.0 | 1 |
| Retinoic acid receptor RXR-alpha CHEMBL2061 | EC50 | 6.98 | 6.98 | 105.0 | 1 |
| Retinoic acid receptor gamma CHEMBL2003 | EC50 | 6.43 | 6.43 | 374.0 | 1 |
| Retinoic acid receptor alpha CHEMBL2055 | EC50 | 5.57 | 5.57 | 2690.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Retinoic acid receptor beta | EC50 | = | 21.0 | nM | 7.68 | Transcriptional activation of Retinoic acid receptor RAR beta | 7636843 |
| Retinoic acid receptor RXR-alpha | EC50 | = | 105.0 | nM | 6.98 | Transcriptional activation of Retinoid X receptor RXR alpha | 7636843 |
| Retinoic acid receptor gamma | EC50 | = | 374.0 | nM | 6.43 | Transcriptional activation of Retinoic acid receptor RAR gamma | 7636843 |
| Retinoic acid receptor alpha | EC50 | = | 2690.0 | nM | 5.57 | Transcriptional activation of Retinoic acid receptor RAR alpha | 7636843 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7636843 | 10.1021/jm00015a004 | Retinoic acid receptor alpha | 1 |
| 7636843 | 10.1021/jm00015a004 | Retinoic acid receptor beta | 1 |
| 7636843 | 10.1021/jm00015a004 | Retinoic acid receptor gamma | 1 |
| 7636843 | 10.1021/jm00015a004 | Retinoic acid receptor RXR-alpha | 1 |
Data from ChEMBL 36 via Core Engine