Assay Detail
ADMET
CHEMBL799768
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound evaluated in vivo and negative logarithm of effective dose divided by estimated volume of distribution (67 mL/kg) determined
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design of potent and selective antagonists of the vasopressor responses to arginine-vasopressin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 8.00 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268067 | — | — | 1 | 8.52 |
| CHEMBL414295 | — | — | 1 | 8.36 |
| CHEMBL266176 | — | — | 1 | 8.35 |
| CHEMBL385080 | — | — | 1 | 8.29 |
| CHEMBL406213 | — | — | 1 | 8.18 |
| CHEMBL266700 | — | — | 1 | 7.97 |
| CHEMBL264246 | — | — | 1 | 7.96 |
| CHEMBL414719 | — | — | 1 | 7.92 |
| CHEMBL384787 | — | — | 1 | 7.82 |
| CHEMBL414467 | — | — | 1 | 7.68 |
| CHEMBL405310 | — | — | 1 | 7.45 |
| CHEMBL412947 | — | — | 1 | 7.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268067 | — | Kd | = | 3.02 | nM | 8.52 |
| CHEMBL414295 | — | Kd | = | 4.365 | nM | 8.36 |
| CHEMBL266176 | — | Kd | = | 4.467 | nM | 8.35 |
| CHEMBL385080 | — | Kd | = | 5.129 | nM | 8.29 |
| CHEMBL406213 | — | Kd | = | 6.607 | nM | 8.18 |
| CHEMBL266700 | — | Kd | = | 10.72 | nM | 7.97 |
| CHEMBL264246 | — | Kd | = | 10.96 | nM | 7.96 |
| CHEMBL414719 | — | Kd | = | 12.02 | nM | 7.92 |
| CHEMBL384787 | — | Kd | = | 15.14 | nM | 7.82 |
| CHEMBL414467 | — | Kd | = | 20.89 | nM | 7.68 |
| CHEMBL405310 | — | Kd | = | 35.48 | nM | 7.45 |
| CHEMBL412947 | — | Kd | = | 35.48 | nM | 7.45 |