Assay Detail
Functional
CHEMBL799773
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Compound was evaluated for the pA2 values against Norepinephrine (NE)-induced contraction of isolated rat vas deferens
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Vas deferens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antidopaminergic activity of some 3-(aminomethyl)tetralones as analogues of butyrophenone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.90 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308480 | — | — | 1 | 7.08 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.99 |
| CHEMBL310153 | — | — | 1 | 6.76 |
| CHEMBL310734 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308480 | — | Kd | = | 83.18 | nM | 7.08 |
| CHEMBL54 | HALOPERIDOL | Kd | = | 102.33 | nM | 6.99 |
| CHEMBL310153 | — | Kd | = | 173.78 | nM | 6.76 |
| CHEMBL310734 | — | Kd | = | 177.83 | nM | 6.75 |