Assay Detail
Binding
CHEMBL799876
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Binding affinity for Retinoic acid receptor alpha
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of 1,2,3,4-tetrahydroquinoline and 3,4-(1H)-dihydroquinolin-2-one analogs of retinoic acid
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 6.72 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275311 | — | — | 1 | 7.44 |
| CHEMBL80271 | — | — | 1 | 7.28 |
| CHEMBL430616 | — | — | 1 | 7.24 |
| CHEMBL76313 | — | — | 1 | 6.87 |
| CHEMBL311269 | — | — | 1 | 6.20 |
| CHEMBL80820 | — | — | 1 | 5.28 |
| CHEMBL308967 | — | — | 1 | - |
| CHEMBL306999 | — | — | 1 | - |
| CHEMBL80934 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275311 | — | Kd | = | 36.0 | nM | 7.44 |
| CHEMBL80271 | — | Kd | = | 52.0 | nM | 7.28 |
| CHEMBL430616 | — | Kd | = | 58.0 | nM | 7.24 |
| CHEMBL76313 | — | Kd | = | 136.0 | nM | 6.87 |
| CHEMBL311269 | — | Kd | = | 627.0 | nM | 6.20 |
| CHEMBL80820 | — | Kd | = | 5202.0 | nM | 5.28 |
| CHEMBL308967 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL306999 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL80934 | — | Kd | > | 1000.0 | nM | - |