Assay Detail
Functional
CHEMBL799883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to cause 50% inhibition of spontaneous activity in rat portal vein
39
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity studies of potassium channel opening in pinacidil-type cyanoguanidines, nitroethenediamines, thioureas, and ureas.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.19 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11458 | — | — | 1 | 8.70 |
| CHEMBL2115097 | — | — | 2 | 8.00 |
| CHEMBL75020 | — | — | 1 | 7.90 |
| CHEMBL2115176 | — | — | 1 | 7.80 |
| CHEMBL75172 | — | — | 1 | 7.80 |
| CHEMBL557537 | — | — | 1 | 7.50 |
| CHEMBL398879 | (R)-PINACIDIL | — | 1 | 7.47 |
| CHEMBL75584 | — | — | 1 | 7.30 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 7.20 |
| CHEMBL2114145 | — | — | 2 | 7.00 |
| CHEMBL77571 | — | — | 1 | 7.00 |
| CHEMBL74146 | — | — | 1 | 6.70 |
| CHEMBL75362 | — | — | 1 | 6.70 |
| CHEMBL2094045 | — | — | 1 | 6.50 |
| CHEMBL431391 | — | — | 1 | 6.50 |
| CHEMBL2093881 | — | — | 1 | 6.30 |
| CHEMBL251647 | (S)-PINACIDIL | — | 1 | 6.11 |
| CHEMBL75857 | — | — | 1 | 6.00 |
| CHEMBL77854 | — | — | 1 | 6.00 |
| CHEMBL307741 | — | — | 1 | 6.00 |
| CHEMBL74245 | — | — | 1 | 6.00 |
| CHEMBL2114147 | — | — | 1 | 5.80 |
| CHEMBL75585 | — | — | 1 | 5.70 |
| CHEMBL73592 | — | — | 1 | 5.70 |
| CHEMBL76996 | — | — | 1 | 5.70 |
| CHEMBL74732 | — | — | 1 | 5.50 |
| CHEMBL539267 | — | — | 1 | 5.50 |
| CHEMBL78117 | — | — | 1 | 5.50 |
| CHEMBL75622 | — | — | 1 | 5.50 |
| CHEMBL311157 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11458 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL2115097 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL75020 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL75172 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL2115176 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL557537 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL398879 | (R)-PINACIDIL | IC50 | = | 33.88 | nM | 7.47 |
| CHEMBL75584 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL77571 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2114145 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL74146 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL75362 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL2094045 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL431391 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL2093881 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL251647 | (S)-PINACIDIL | IC50 | = | 776.25 | nM | 6.11 |
| CHEMBL74245 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL307741 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL77854 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL75857 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2115097 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2114147 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL75585 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL76996 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL73592 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL78117 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL75622 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL74732 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL539267 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL311157 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL2114145 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL75062 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL75965 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL308334 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL307840 | — | IC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL305882 | — | IC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL76594 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL307913 | — | IC50 | < | 10000.0 | nM | - |