Assay Detail
Binding
CHEMBL800045
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Inhibitory effect on HIV-1 RT activity using template primer,poly (rA)-oligo (dT)
8
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Thiadiazole derivatives: highly potent and specific HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.82 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 2 | 8.22 |
| CHEMBL37624 | LOVIRIDE | 2.0 | 2 | 6.30 |
| CHEMBL62905 | — | — | 2 | 5.77 |
| CHEMBL62196 | — | — | 1 | 5.47 |
| CHEMBL60314 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL37624 | LOVIRIDE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL62905 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL62196 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL60314 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL62905 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL37624 | LOVIRIDE | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL129 | ZIDOVUDINE | IC50 | > | 50000.0 | nM | - |