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Compound Detail

CHEMBL37624

LOVIRIDE
🧪 Phase II
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🧪 Phase II
CC(=O)c1ccc(C)cc1NC(C(N)=O)c1c(Cl)cccc1Cl
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL37624
Name LOVIRIDE
Phase Phase II
Structure Type MOL
InChI Key CJPLEFFCVDQQFZ-UHFFFAOYSA-N

Known Names

Lovirida Loviride R-89439
5
Targets
23
Activities
2
Assay Types
0
PK Parameters
15
Publications
3
Known Names

Molecular Properties

351.2
MW (Da)
4.14
ALogP
3
HBA
2
HBD
72.2
PSA (Ų)
0.80
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Racemic

Flags

Natural Product
USAN Stem -vir-
USAN Year 1997

Extended Properties

Molecular Formula C17H16Cl2N2O2
MW 351.23
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -0.96

Activity Summary

IC50 14 meas. best 8.22
EC50 9 meas. best 8.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Human immunodeficiency virus 1
CHEMBL378
 IC50 8.22 7.74 6.0 4
MT4
CHEMBL388
 EC50 8.22 6.4 6.0 6
Human immunodeficiency virus type 1 reverse transcriptase
CHEMBL247
 EC50 7.89 7.89 13.0 1
Human immunodeficiency virus 1
CHEMBL378
 EC50 7.89 7.89 13.0 1
MT4
CHEMBL388
 IC50 7.3 6.05 50.0 8
Homo sapiens
CHEMBL372
 EC50 6.96 6.96 110.0 1
Human immunodeficiency virus type 1 protease
CHEMBL243
 IC50 6.3 5.55 500.0 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
MT4 EC50 = 6.0 nM 8.22 Compound was evaluated for the inhibition of HIV-1 induced CPE (HTLV-III B strai... 7540208
Human immunodeficiency virus 1 IC50 = 6.0 nM 8.22 Concentration required to inhibit the viral (HIV-1 NL4.3 strain) cytopathic effe... 12672256
MT4 EC50 = 13.0 nM 7.89 Effective concentration of the compound to inhibit HIV-1 mutant LAI replication ... 15771411
Human immunodeficiency virus 1 EC50 = 13.0 nM 7.89 Antiviral activity against Human immunodeficiency virus 1 infected in human MT4 ... 19632850
Human immunodeficiency virus type 1 reverse transcriptase EC50 = 13.0 nM 7.89 Inhibition of HIV1 reverse transcriptase 30223123
Human immunodeficiency virus 1 IC50 = 13.0 nM 7.89 Antiviral activity against HIV1 3B infected in MT4 cells assessed as inhibition ... 22268494
Human immunodeficiency virus 1 IC50 = 14.0 nM 7.85 Concentration required to inhibit the viral (HIV-1 IIIB strain) cytopathic effec... 12672256
MT4 EC50 = 50.0 nM 7.3 Effective concentration of the compound to inhibit HIV-1 mutant L100I replicatio... 15771411
MT4 IC50 = 50.0 nM 7.3 Compound was tested for potency to achieve protection of MT-4 cells from LAI str... 11527703
MT4 IC50 = 50.0 nM 7.3 Compound was tested for potency to achieve protection of MT-4 cells from 100I st... 11527703
MT4 IC50 = 63.0 nM 7.2 Compound was tested for potency to achieve protection of MT-4 cells from 101E st... 11527703
Human immunodeficiency virus 1 IC50 = 100.0 nM 7.0 Concentration required to inhibit 50% viral production of human immunodeficiency... 15801834
Homo sapiens EC50 = 110.0 nM 6.96 Compound was evaluated for the inhibition of HIV-1 induced CPE (HTLV-III B strai... 7540208
Human immunodeficiency virus type 1 protease IC50 = 500.0 nM 6.3 Inhibitory effect on HIV-1 RT activity using template primer,poly (rA)-oligo (dT... 7540208
MT4 IC50 = 1000.0 nM 6.0 Compound was tested for potency to achieve protection of MT-4 cells from 106A st... 11527703
MT4 IC50 = 1260.0 nM 5.9 Compound was tested for potency to achieve protection of MT-4 cells from 103N st... 11527703
MT4 EC50 = 1300.0 nM 5.89 Effective concentration of the compound to inhibit HIV-1 mutant K103N replicatio... 15771411
MT4 IC50 = 2510.0 nM 5.6 Compound was tested for potency to achieve protection of MT-4 cells from 190A st... 11527703
MT4 EC50 = 16000.0 nM 4.8 Effective concentration of the compound to inhibit HIV-1 mutant Y181C replicatio... 15771411
MT4 IC50 = 15800.0 nM 4.8 Compound was tested for potency to achieve protection of MT-4 cells from 181C st... 11527703

Literature References

PubMed DOI Target Context # Activities
11527703 10.1016/s0960-894x(01)00410-3 MT4 8
15771411 10.1021/jm040127p MT4 5
12672256 10.1021/jm0211117 Human immunodeficiency virus 1 3
7540208 10.1021/jm00012a002 MT4 2
7540208 10.1021/jm00012a002 Unchecked 2
7540208 10.1021/jm00012a002 Human immunodeficiency virus type 1 protease 2
7540208 10.1021/jm00012a002 Homo sapiens 2
12672256 10.1021/jm0211117 Human immunodeficiency virus 2 1
12672256 10.1021/jm0211117 Simian immunodeficiency virus 1
12672256 10.1021/jm0211117 MT4 1
15801834 10.1021/jm049606e Human immunodeficiency virus 1 1
19632850 10.1016/j.bmc.2009.06.060 NON-PROTEIN TARGET 1
19632850 10.1016/j.bmc.2009.06.060 Human immunodeficiency virus 1 1
22268494 10.1021/jm200990c Human immunodeficiency virus 1 1
30223123 10.1016/j.ejmech.2018.09.013 Human immunodeficiency virus type 1 reverse transcriptase 1

Data from ChEMBL 36 via Core Engine