Assay Detail
Functional
CHEMBL713935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit the viral (HIV-1 NL4.3 strain) cytopathic effect by 50% in MT-4 cells.
62
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 5.37 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37624 | LOVIRIDE | 2.0 | 1 | 8.22 |
| CHEMBL273996 | — | — | 1 | 6.20 |
| CHEMBL38489 | — | — | 1 | 6.06 |
| CHEMBL289423 | — | — | 1 | 5.89 |
| CHEMBL38470 | — | — | 1 | 5.72 |
| CHEMBL289785 | — | — | 1 | 5.66 |
| CHEMBL285907 | — | — | 1 | 5.61 |
| CHEMBL289210 | — | — | 1 | 5.45 |
| CHEMBL289726 | — | — | 1 | 5.34 |
| CHEMBL290159 | — | — | 1 | 5.28 |
| CHEMBL37967 | — | — | 1 | 5.25 |
| CHEMBL287131 | — | — | 1 | 5.18 |
| CHEMBL288587 | — | — | 1 | 5.05 |
| CHEMBL39414 | — | — | 1 | 5.05 |
| CHEMBL290703 | — | — | 1 | 5.01 |
| CHEMBL39904 | — | — | 1 | 4.96 |
| CHEMBL288680 | — | — | 1 | 4.95 |
| CHEMBL39135 | — | — | 1 | 4.91 |
| CHEMBL38602 | — | — | 1 | 4.73 |
| CHEMBL288964 | — | — | 1 | 4.68 |
| CHEMBL39115 | — | — | 1 | 4.63 |
| CHEMBL39683 | — | — | 1 | 4.38 |
| CHEMBL38690 | — | — | 1 | - |
| CHEMBL289591 | — | — | 1 | - |
| CHEMBL289090 | — | — | 1 | - |
| CHEMBL288727 | — | — | 1 | - |
| CHEMBL39101 | — | — | 1 | - |
| CHEMBL289379 | — | — | 1 | - |
| CHEMBL39105 | — | — | 1 | - |
| CHEMBL290902 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37624 | LOVIRIDE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL273996 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL38489 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL289423 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL38470 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL289785 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL285907 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL289210 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL289726 | — | IC50 | = | 4520.0 | nM | 5.34 |
| CHEMBL290159 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL37967 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL287131 | — | IC50 | = | 6580.0 | nM | 5.18 |
| CHEMBL39414 | — | IC50 | = | 8990.0 | nM | 5.05 |
| CHEMBL288587 | — | IC50 | = | 8910.0 | nM | 5.05 |
| CHEMBL290703 | — | IC50 | = | 9790.0 | nM | 5.01 |
| CHEMBL39904 | — | IC50 | = | 10990.0 | nM | 4.96 |
| CHEMBL288680 | — | IC50 | = | 11250.0 | nM | 4.95 |
| CHEMBL39135 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL38602 | — | IC50 | = | 18440.0 | nM | 4.73 |
| CHEMBL288964 | — | IC50 | = | 20980.0 | nM | 4.68 |
| CHEMBL39115 | — | IC50 | = | 23270.0 | nM | 4.63 |
| CHEMBL39683 | — | IC50 | = | 41960.0 | nM | 4.38 |
| CHEMBL289913 | — | IC50 | > | 45630.0 | nM | - |
| CHEMBL290093 | — | IC50 | > | 213680.0 | nM | - |
| CHEMBL290020 | — | IC50 | > | 38690.0 | nM | - |
| CHEMBL288161 | — | IC50 | > | 126420.0 | nM | - |
| CHEMBL39070 | — | IC50 | > | 30820.0 | nM | - |
| CHEMBL287787 | — | IC50 | > | 42630.0 | nM | - |
| CHEMBL290021 | — | IC50 | > | 40800.0 | nM | - |
| CHEMBL291259 | — | IC50 | > | 49960.0 | nM | - |
| CHEMBL288427 | — | IC50 | > | 53040.0 | nM | - |
| CHEMBL39815 | — | IC50 | > | 33150.0 | nM | - |
| CHEMBL40011 | — | IC50 | > | 160570.0 | nM | - |
| CHEMBL291072 | — | IC50 | > | 180790.0 | nM | - |
| CHEMBL290093 | — | IC50 | > | 67290.0 | nM | - |
| CHEMBL290648 | — | IC50 | > | 39660.0 | nM | - |
| CHEMBL279411 | — | IC50 | > | 120030.0 | nM | - |
| CHEMBL38391 | — | IC50 | > | 67360.0 | nM | - |
| CHEMBL38556 | — | IC50 | > | 33240.0 | nM | - |
| CHEMBL39462 | — | IC50 | > | 42160.0 | nM | - |
| CHEMBL288706 | — | IC50 | > | 147120.0 | nM | - |
| CHEMBL38980 | — | IC50 | > | 36310.0 | nM | - |
| CHEMBL290902 | — | IC50 | > | 191270.0 | nM | - |
| CHEMBL289591 | — | IC50 | > | 27870.0 | nM | - |
| CHEMBL39105 | — | IC50 | > | 48800.0 | nM | - |
| CHEMBL289379 | — | IC50 | > | 106700.0 | nM | - |
| CHEMBL39101 | — | IC50 | > | 190310.0 | nM | - |
| CHEMBL288727 | — | IC50 | > | 44700.0 | nM | - |
| CHEMBL38690 | — | IC50 | > | 259420.0 | nM | - |
| CHEMBL289090 | — | IC50 | > | 187130.0 | nM | - |