Assay Detail
Functional
CHEMBL711462
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Compound was evaluated for the inhibition of HIV-1 induced CPE (HTLV-III B strain ) replication in MT-4 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Thiadiazole derivatives: highly potent and specific HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.12 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.40 |
| CHEMBL37624 | LOVIRIDE | 2.0 | 1 | 8.22 |
| CHEMBL60314 | — | — | 1 | 7.89 |
| CHEMBL62905 | — | — | 1 | 7.41 |
| CHEMBL62196 | — | — | 1 | 7.41 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.14 |
| CHEMBL64381 | — | — | 1 | 7.00 |
| CHEMBL62238 | — | — | 1 | 6.62 |
| CHEMBL292028 | — | — | 1 | 6.50 |
| CHEMBL294325 | — | — | 1 | 4.64 |
| CHEMBL62690 | — | — | 1 | - |
| CHEMBL292265 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL37624 | LOVIRIDE | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL60314 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL62905 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL62196 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL64381 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL62238 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL292028 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL294325 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL62690 | — | EC50 | > | 560000.0 | nM | - |
| CHEMBL292265 | — | EC50 | > | 535000.0 | nM | - |