Assay Detail
Functional
CHEMBL800239
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Alpha-1-adrenoceptor blocking activity by antagonism of (-)-norepinephrine induced contractions of epididymal portion of rat vas deferens
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Vas deferens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationships among benextramine-related tetraamine disulfides. Chain length effect on alpha-adrenoreceptor blocking activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.49 | 5.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53810 | — | — | 1 | 5.14 |
| CHEMBL19060 | BENEXTRAMINE | — | 1 | 5.12 |
| CHEMBL1202698 | — | — | 1 | 5.08 |
| CHEMBL52739 | — | — | 1 | 4.33 |
| CHEMBL1202699 | — | — | 1 | 4.29 |
| CHEMBL55957 | — | — | 1 | 4.26 |
| CHEMBL301293 | — | — | 1 | 4.25 |
| CHEMBL1202700 | — | — | 1 | 4.20 |
| CHEMBL1202701 | — | — | 1 | 4.17 |
| CHEMBL299486 | — | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53810 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL19060 | BENEXTRAMINE | IC50 | = | 7550.0 | nM | 5.12 |
| CHEMBL1202698 | — | IC50 | = | 8230.0 | nM | 5.08 |
| CHEMBL52739 | — | IC50 | = | 46900.0 | nM | 4.33 |
| CHEMBL1202699 | — | IC50 | = | 51300.0 | nM | 4.29 |
| CHEMBL55957 | — | IC50 | = | 55200.0 | nM | 4.26 |
| CHEMBL301293 | — | IC50 | = | 55800.0 | nM | 4.25 |
| CHEMBL1202700 | — | IC50 | = | 62800.0 | nM | 4.20 |
| CHEMBL1202701 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL299486 | — | IC50 | = | 98500.0 | nM | 4.01 |